For best results take at least two times a day and preferably add to 8 oz’s of water as the last drink of the day and then take as the first drink of the day when you get up the next morning. Your kidneys detox between 2 am and 4 am so this helps rid your connective tissues of acid during this critical time in your bodies repair cycle. Lowering the acidity in your body will help in the weight loss process.